Kelle H. Moley, M.D.

Kelle Pic

Kelle H. Moley, M.D., co-directs the Institute of Clinical and Translational Sciences at Washington University in St. Louis, MO.  She is a professor of obstetrics and gynecology and was named vice chair for basic science research and director of the Division of Basic Science Research in the Department of Obstetrics and Gynecology at Washington University School of Medicine in St. Louis in March 2006 and the inaugural James P. Crane Professor of Obstetrics and Gynecology in June 2009.  As part of her appointment, Moley is responsible for developing a strategic plan and direction for the new division and enhancing the current program in Reproductive Science.

Also a professor in cell biology and physiology, Moley is one of a handful of people in the world studying the effects of maternal type 1 and type 2 diabetes and obesity on gametes, implantation and development of mice embryos.  Her work has established that short term exposure to high concentrations of glucose or insulin during the first 72 hours following fertilization is enough to alter the embryos and result in the increase in congenital malformations and miscarriages, as seen in women with diabetes and other metabolic disorders.

She also is known for cloning and characterizing two novel glucose transporters, GLUT8 and GLUT9.  Her work on these proteins demonstrates altered location and expression of these transporters in response to insulin exposure and diabetes, respectively.  Her research has impacted our understanding of reproductive performance and glucose utilization in diabetic animal models how this may be applicable to the pathophysiology of diabetes in humans.  She is principal investigator on several NIH grants exploring reproductive biology.

Moley is director of the Fellowship Program in Reproductive Endocrinology and the Clinical Mentorship Program for the University’s Markey Pathway, a graduate program that provides students with a deeper understanding of the nature of disease.  She is also Principal Investigator on the first National Institute of Health training grant for PhDs interested in Reproductive Sciences awarded to the Department of Obstetrics and Gynecology at Washington University School of Medicine.  She is Director of the Women’s Reproductive Health Research Award at Washington University.